Poly(lactide-co-glycolide) (PLGA) (Medical level)

Chemical name

Poly(L-lactide-co-glycolide)

Product Model

PLG

Chemical formula

(C₆H₈O₄)_m (C₄H₄O₄)_n

CAS registry number

30846-39-0

Chemical Structure

Instructions: The alternate name of poly(L-lactide-co-glycolide) (PLGA), is polylactic acid-glycollic acid copolymer. PLGA is produced from lactic acid and glycolic acid. It is non-toxic and has excellent biodegradability, biocompatibility, film or capsule forming ability. PLGA is widely used in pharmaceutical, medical engineering materials and modern industrial fields. In the United States, PLGA has been approved by the FDA and is formally included in the United States pharmacopoeia as pharmaceutical materials.

PLGA is a amorphous polymer. The glass transition temperature (Tg) of PLGA is 40 - 60 °C. It has been widely used in medical surgical sutures, anti-adhesion membrane, tissue engineering scaffolds and so on. The degradation rate of PLGA increases with the increase of GA proportion. Different types of PLGA can be produced using different monomer ratio . For example, PLGA 75:25 indicates that the polymer consists of 75% lactic acid and 25% glycolic acid.

The degradation products of PLGA are lactic acid and glycolic acid, so they do not have toxic side effects when used as the pharmaceutical and biological materials. PLGA has been widely used in biomedical fields, such as medical anti-adhesion membrane, skin graft, stitched wound, injectable microcapsules, microspheres, implants,scaffolds for tissue engineering.

Model

Ratio LA/GA

IV

LA/GA Proportional Range

IV Range

dL/g

PLG90-03

90/10

0.3

87/13-93/7

0.20-0.40

PLG90-05

90/10

0.5

87/13-93/7

0.40-0.70

PLG90-08

90/10

0.8

87/13-93/7

0.70-1.00

PLG90-12

90/10

1.2

87/13-93/7

1.00-1.40

PLG90-16

90/10

1.6

87/13-93/7

1.40-1.80

PLG90-20

90/10

2.0

87/13-93/7

>1.80

PLG80-03

80/20

0.3

77/23-83/17

0.20-0.40

PLG80-05

80/20

0.5

77/23-83/17

0.40-0.70

PLG80-08

80/20

0.8

77/23-83/17

0.70-1.00

PLG80-12

80/20

1.2

77/23-83/17

1.00-1.40

PLG80-16

80/20

1.6

77/23-83/17

1.40-1.80

PLG80-20

80/20

2.0

77/23-83/17

>1.80

PLG75-03

75/25

0.3

72/28-78/22

0.20-0.40

PLG75-05

75/25

0.5

72/28-78/22

0.40-0.70